DEVELOPMENT OF NEW EXPRESSION SYSTEMS FOR MAMMALIAN CELLS
   PanGen has continuously been developing various new vector systems for mammalian cells (CHO, BHK, HEK-293) as well as yeast and E. coli.  The new systems are designed to be easier and faster in the expression of a particular gene.

DEVELOPMENT OF CELL LINES FOR LARGE SCALE PRODUCTION OF WELL-KNOWN PROTEINS OR ANTIBODIES
   Many stable cell lines of well-known therapeutic proteins have been developed for large scale production using PanGen's proprietary technology.

AUTOMATION FOR CHO CELL LINE DEVELOPMENT
   PanGen is designing and building an automated cell culture system which improve the quality control and efficiency of generating cell lines, even further.

DEVELOPMENT OF HIGH THROUGHPUT DRUG SCREENING (HTS) SYSTEM
   PanGen provides a high throughput drug screening system for GPCRs, expressing in CHO cells.  Such cell line will be applied for in vivo drug screening for the particular cell types such as in the case of neuron specific proteins, for example.

GENOMICS USING CHO CELL TECHNOLOGY
   It is no secret that many companies are now racing to discover new therapeutically valuable protein drugs from the sequence data obtained from the Human Genome Project.  Most companies are using E. coli or yeast technology because they are faster and easier to work with.  However, PanGen believes that those companies will eventualy turn their attention to CHO cells because those proteins have more therapeutic value.  Therefore, PanGen is developing hundreds of cell lines for genes of unknown function relying on our advanced CHO cell vector technology and internally developed automated cell culture system.  PanGen is ready to collaborate with other interested companies who are positioned to discover new therapeutically valuable proteins through gene hunting and genomics research.